Version 5.4
Homo sapiens Gene: CD300LF
Summary
InnateDB Gene IDBG-67452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD300LF
Gene Name CD300 molecule-like family member f
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186074
Encoded Proteins
IDBP-67454
CD300 molecule-like family member f
IDBP-67456
CD300 molecule-like family member f
IDBP-67460
CD300 molecule-like family member f
IDBP-67462
CD300 molecule-like family member f
IDBP-760219
IDBP-757880
IDBP-758205
IDBP-760940
IDBP-760792
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22043923
CD300LF inhibits MYD88 and/or TRIF-mediated TLR signalling pathway through the dual activation of PTPN6 and PTPN11.
InnateDB Annotation from Orthologs
Summary
PMID 22043923
[Mus musculus] Cd300lf inhibits Myd88 and/or TRIF-mediated TLR signalling pathway through the dual activation of Ptpn6 and Ptpn11. (Demonstrated in human)
Entrez Gene
Summary CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004 [PubMed 15184070]; Alvarez-Errico et al., 2004 [PubMed 15549731]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74694311-74712978
Strand Reverse strand
Band q25.1
Transcripts
ENST00000326165 ENSP00000327075
ENST00000343125 ENSP00000343751
ENST00000301573 ENSP00000301573
ENST00000361254 ENSP00000355294
ENST00000469092 ENSP00000463743
ENST00000464910 ENSP00000464257
ENST00000462044 ENSP00000464223
ENST00000581500 ENSP00000464610
ENST00000583937 ENSP00000462309
ENST00000583544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000047798
View Gene Order
Cross-References
SwissProt Q8TDQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 146722
UniGene Hs.567706
RefSeq NM_001289082 NM_001289083 NM_001289084 NM_001289085 NM_001289086 NM_001289087 NM_139018
HUGO HGNC:29883
OMIM 609807
CCDS CCDS74148 CCDS11704 CCDS74149 CCDS74150 CCDS74151 CCDS74152
HPRD 17635
IMGT
EMBL AC016888 AC064805 AF251706 AF375480 AF375481 AK092757 AK315165 AY303545 AY358545 BC028199 DQ153249
GenPept AAH28199 AAM19099 AAP42152 AAP42153 AAP57942 AAQ88909 AAZ81566 BAC03966 BAG37609
RNA Seq Atlas 146722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca