Version 5.4
Homo sapiens Gene: AP2M1
Summary
InnateDB Gene IDBG-67524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP2M1
Gene Name adaptor-related protein complex 2, mu 1 subunit
Synonyms AP50; CLAPM1; mu2
Species Homo sapiens
Ensembl Gene ENSG00000161203
Encoded Proteins
IDBP-67526
adaptor-related protein complex 2, mu 1 subunit
IDBP-67528
adaptor-related protein complex 2, mu 1 subunit
IDBP-385909
adaptor-related protein complex 2, mu 1 subunit
IDBP-385911
adaptor-related protein complex 2, mu 1 subunit
IDBP-385912
adaptor-related protein complex 2, mu 1 subunit
IDBP-385913
adaptor-related protein complex 2, mu 1 subunit
IDBP-385914
adaptor-related protein complex 2, mu 1 subunit
IDBP-385915
adaptor-related protein complex 2, mu 1 subunit
IDBP-385916
adaptor-related protein complex 2, mu 1 subunit
IDBP-385917
adaptor-related protein complex 2, mu 1 subunit
IDBP-807519
adaptor-related protein complex 2, mu 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:184174689-184184091
Strand Forward strand
Band q27.1
Transcripts
ENST00000292807 ENSP00000292807
ENST00000382456 ENSP00000371894
ENST00000427072 ENSP00000402051
ENST00000411763 ENSP00000403362
ENST00000448139 ENSP00000402592
ENST00000455925 ENSP00000404031
ENST00000439647 ENSP00000409081
ENST00000432591 ENSP00000395438
ENST00000431779 ENSP00000404326
ENST00000442686 ENSP00000416688
ENST00000484469
ENST00000487958
ENST00000466598
ENST00000460862
ENST00000472560
ENST00000490151
ENST00000468048
ENST00000461733
ENST00000476434
ENST00000463935
ENST00000480260
ENST00000621863 ENSP00000481563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 136 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030131 clathrin adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022841
View Gene Order
ENSBTAG00000020106
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_11139
Nef mediated downregulation of CD28 cell surface expression pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_9411
Gap junction trafficking pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518460 Hs.713745
RefSeq NM_001025205 NM_004068
HUGO
OMIM
CCDS CCDS43177 CCDS43178
HPRD 03014
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca