InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAGED1

Summary

InnateDB Gene

IDBG-67550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGED1

Gene Name

melanoma antigen family D, 1

Synonyms

DLXIN-1; NRAGE

Species

Homo sapiens

Ensembl Gene

ENSG00000179222

Encoded Proteins

IDBP-67552

melanoma antigen family D, 1

IDBP-67554

melanoma antigen family D, 1

IDBP-67556

melanoma antigen family D, 1

IDBP-67558

melanoma antigen family D, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:51803007-51902357

Strand

Forward strand

Band

p11.22

Transcripts

ENST00000375772	ENSP00000364927
ENST00000375722	ENSP00000364874
ENST00000326587	ENSP00000325333
ENST00000375695	ENSP00000364847
ENST00000470461
ENST00000494718
ENST00000485420
ENST00000482188
ENST00000482599
ENST00000473931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	82 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0097190	apoptotic signaling pathway
GO:2001235	positive regulation of apoptotic signaling pathway