Version 5.4
Homo sapiens Gene: ECE2
Summary
InnateDB Gene IDBG-67656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECE2
Gene Name endothelin converting enzyme 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145194
Encoded Proteins
IDBP-67658
endothelin converting enzyme 2
IDBP-67662
endothelin converting enzyme 2
IDBP-67664
endothelin converting enzyme 2
IDBP-293709
endothelin converting enzyme 2
IDBP-293695
endothelin converting enzyme 2
IDBP-385986
endothelin converting enzyme 2
IDBP-385987
endothelin converting enzyme 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 [PubMed 11718899]).[supplied by OMIM, Mar 2008]
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:184249650-184293031
Strand Forward strand
Band q27.1
Transcripts
ENST00000324557 ENSP00000314295
ENST00000359140 ENSP00000352052
ENST00000357474 ENSP00000350066
ENST00000402825 ENSP00000384223
ENST00000404464 ENSP00000385846
ENST00000422932 ENSP00000392467
ENST00000430587 ENSP00000398444
ENST00000488401
ENST00000474750
ENST00000490579
ENST00000462596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0007420 brain development
GO:0007507 heart development
GO:0008152 metabolic process
GO:0010002 cardioblast differentiation
GO:0016486 peptide hormone processing
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022842
View Gene Order
ENSBTAG00000005658
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.146161 Hs.585003
RefSeq NM_001037324 NM_001100120 NM_001100121 NM_014693 NM_032331
HUGO
OMIM
CCDS CCDS3255 CCDS3256 CCDS33899 CCDS43179 CCDS46969
HPRD 09931
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca