Homo sapiens Gene: DBI | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-67980.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | DBI | ||||||||||||||||||
Gene Name | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | ||||||||||||||||||
Synonyms | ACBD1; ACBP; CCK-RP; EP | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000155368 | ||||||||||||||||||
Encoded Proteins |
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:119366921-119372560 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q14.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
PPAR signaling pathway pathway
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INOH |
GPCR signaling pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P07108 | ||||||||||||||||||
TrEMBL | B8ZWD1 B8ZWD8 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1622 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001178043 NM_001079862 NM_001079863 NM_001178042 NM_001282633 NM_001282634 NM_001282635 NM_020548 | ||||||||||||||||||
HUGO | HGNC:2690 | ||||||||||||||||||
OMIM | 125950 | ||||||||||||||||||
CCDS | CCDS74568 CCDS2126 CCDS42740 CCDS42741 | ||||||||||||||||||
HPRD | 08832 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC016736 AM000001 BC006466 BC062996 CH471103 CR456956 FM213122 FM213123 FM213124 FM213125 FM213126 FM213127 FM213128 FM213129 FM213131 M14200 M15887 | ||||||||||||||||||
GenPept | AAA35788 AAA52171 AAH62996 AAY14873 CAG33237 CAJ00736 CAR82404 CAR82405 CAR82406 CAR82407 CAR82408 CAR82409 CAR82410 CAR82411 CAR82414 EAW95214 | ||||||||||||||||||
RNA Seq Atlas | 1622 | ||||||||||||||||||