Version 5.4
Homo sapiens Gene: SLC16A5
Summary
InnateDB Gene IDBG-67985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A5
Gene Name solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
Synonyms MCT5; MCT6
Species Homo sapiens
Ensembl Gene ENSG00000170190
Encoded Proteins
IDBP-67987
solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
IDBP-384255
solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
IDBP-599403
solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
IDBP-759847
IDBP-757682
IDBP-764884
IDBP-761250
IDBP-762833
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75087727-75106162
Strand Forward strand
Band q25.1
Transcripts
ENST00000329783 ENSP00000330141
ENST00000450736 ENSP00000390564
ENST00000538213 ENSP00000440212
ENST00000578376 ENSP00000463363
ENST00000584207 ENSP00000462267
ENST00000584118 ENSP00000463931
ENST00000580123 ENSP00000463434
ENST00000578847 ENSP00000462866
ENST00000582048
ENST00000585293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045775
View Gene Order
ENSBTAG00000001110
Not yet available
Cross-References
SwissProt
TrEMBL A0A024R8S0 B4E288 J3KT93 J3QL40 J3QQW5
UniProt Splice Variant
Entrez Gene 9121
UniGene Hs.592095
RefSeq XM_005257791 NM_001271765 NM_004695 XM_005257790 XM_006722170
HUGO HGNC:10926
OMIM 603879
CCDS CCDS11713
HPRD 04856
IMGT
EMBL AC111186 AK304163 CH471099
GenPept BAG65050 EAW89233 EAW89234 EAW89235
RNA Seq Atlas 9121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca