Version 5.4
Homo sapiens Gene: CNOT3
Summary
InnateDB Gene IDBG-68161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT3
Gene Name CCR4-NOT transcription complex, subunit 3
Synonyms LENG2; NOT3; NOT3H
Species Homo sapiens
Ensembl Gene ENSG00000088038
Encoded Proteins
IDBP-68163
CCR4-NOT transcription complex, subunit 3
IDBP-68165
CCR4-NOT transcription complex, subunit 3
IDBP-384568
CCR4-NOT transcription complex, subunit 3
IDBP-384570
CCR4-NOT transcription complex, subunit 3
IDBP-384572
CCR4-NOT transcription complex, subunit 3
IDBP-485631
CCR4-NOT transcription complex, subunit 3
IDBP-810969
CCR4-NOT transcription complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54137728-54155681
Strand Forward strand
Band q13.42
Transcripts
ENST00000221232 ENSP00000221232
ENST00000358389 ENSP00000351159
ENST00000440571 ENSP00000398463
ENST00000447684 ENSP00000411587
ENST00000457463 ENSP00000401703
ENST00000496327
ENST00000471126 ENSP00000420064
ENST00000618939
ENST00000613073 ENSP00000483360
ENST00000617930
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 33 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035632
View Gene Order
ENSBTAG00000014900
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_014516
HUGO
OMIM
CCDS CCDS12880
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca