Version 5.4
Homo sapiens Gene: MRE11A
Summary
InnateDB Gene IDBG-68191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRE11A
Gene Name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Synonyms ATLD; HNGS1; MRE11; MRE11B
Species Homo sapiens
Ensembl Gene ENSG00000020922
Encoded Proteins
IDBP-68193
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-68195
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-244013
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-294124
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-596948
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-590983
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
IDBP-589257
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3\' to 5\' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3\' to 5\' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94415578-94493908
Strand Reverse strand
Band q21
Transcripts
ENST00000323977 ENSP00000326094
ENST00000323929 ENSP00000325863
ENST00000393241 ENSP00000376933
ENST00000407439 ENSP00000385614
ENST00000535120
ENST00000540013 ENSP00000440986
ENST00000541157
ENST00000536754 ENSP00000439511
ENST00000538923 ENSP00000442809
ENST00000536144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 119 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007126 meiotic nuclear division
GO:0007129 synapsis
GO:0007131 reciprocal meiotic recombination
GO:0008283 cell proliferation
GO:0031573 intra-S DNA damage checkpoint
GO:0031954 positive regulation of protein autophosphorylation
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0032876 negative regulation of DNA endoreduplication
GO:0033674 positive regulation of kinase activity
GO:0045087 innate immune response
GO:0051276 chromosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0030870 Mre11 complex
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031928
View Gene Order
ENSBTAG00000008925
Not yet available
Pathways
NETPATH
REACTOME
REACT_147841
STING mediated induction of host immune responses pathway
REACT_486
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
REACT_1884
MRN complex relocalizes to nuclear foci pathway
REACT_97
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_27271
Meiotic recombination pathway
REACT_120956
Cellular responses to stress pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_6802
Innate Immune System pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_111183
Meiosis pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_216
DNA Repair pathway
KEGG
hsa03450
Non-homologous end-joining pathway
hsa03440
Homologous recombination pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
bard1pathway
BARD1 signaling events
atm_pathway
ATM pathway
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P49959
TrEMBL F5H256 F5H742 Q9BS79
UniProt Splice Variant
Entrez Gene 4361
UniGene Hs.192649
RefSeq NM_005590 NM_005591 XM_005274007 XM_005274008 XM_006718842
HUGO HGNC:7230
OMIM 600814
CCDS CCDS8298 CCDS8299
HPRD 02889
IMGT
EMBL AF022778 AF073362 AF303379 AF303380 AF303381 AF303382 AF303383 AF303384 AF303385 AF303386 AF303387 AF303388 AF303389 AF303390 AF303391 AF303392 AF303393 AF303394 AF303395 AP000765 AP000786 AY584241 BC005241 BC063458 BT006730 U37359
GenPept AAC36249 AAC78721 AAD10197 AAH05241 AAH63458 AAK18790 AAP35376 AAS79320
RNA Seq Atlas 4361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca