Version 5.4
Homo sapiens Gene: ITGB1
Summary
InnateDB Gene IDBG-68302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB1
Gene Name integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Synonyms CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB
Species Homo sapiens
Ensembl Gene ENSG00000150093
Encoded Proteins
IDBP-68308
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-238288
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-372348
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-372354
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-372358
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-372362
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-477455
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-477371
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-483245
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-477489
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-483856
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-478030
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-482274
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-481054
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-592515
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
IDBP-589720
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20877569
ITGB1 along with ITGA3 is a novel regulator for the recognition of bacterial lipopeptides. ITGB1/ITGA3 integrin regulates endosomal Toll-like receptor (TLR)-2/TLR1 signalling, serving as a mechanism for modulating inflammatory responses.
PMID 26288256
IFNG primes mast cells for enhanced anti-bacterial and pro-inflammatory responses to Staphylococcus aureus, partially mediated by ITGB1.
Entrez Gene
Summary Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:32900319-33005792
Strand Reverse strand
Band p11.22
Transcripts
ENST00000302278 ENSP00000303351
ENST00000396033 ENSP00000379350
ENST00000423113 ENSP00000388694
ENST00000437302 ENSP00000398029
ENST00000417122 ENSP00000404546
ENST00000414670 ENSP00000400544
ENST00000488427 ENSP00000417508
ENST00000494395 ENSP00000417799
ENST00000484088
ENST00000480226 ENSP00000417537
ENST00000474568 ENSP00000420282
ENST00000488494 ENSP00000418725
ENST00000475184 ENSP00000417243
ENST00000464001
ENST00000493758 ENSP00000420792
ENST00000472147 ENSP00000420416
ENST00000534049 ENSP00000431326
ENST00000528877 ENSP00000436214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 128 [view]
Protein-Protein 127 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0001948 glycoprotein binding
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0003779 actin binding
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0042277 peptide binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
GO:0051393 alpha-actinin binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001894 tissue homeostasis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006874 cellular calcium ion homeostasis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009615 response to virus
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0014823 response to activity
GO:0016032 viral process
GO:0016477 cell migration
GO:0021943 formation of radial glial scaffolds
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0031345 negative regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0032594 protein transport within lipid bilayer
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034329 cell junction assembly
GO:0034698 response to gonadotropin
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045214 sarcomere organization
GO:0045596 negative regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045807 positive regulation of endocytosis
GO:0048675 axon extension
GO:0048738 cardiac muscle tissue development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0051726 regulation of cell cycle
GO:0055007 cardiac muscle cell differentiation
GO:0060135 maternal process involved in female pregnancy
GO:0070830 tight junction assembly
GO:0071260 cellular response to mechanical stimulus
GO:0071305 cellular response to vitamin D
GO:0071479 cellular response to ionizing radiation
GO:0071559 response to transforming growth factor beta
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0001669 acrosomal vesicle
GO:0001726 ruffle
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030056 hemidesmosome
GO:0030175 filopodium
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0034667 integrin alpha3-beta1 complex
GO:0034677 integrin alpha7-beta1 complex
GO:0034678 alpha8-beta1 integrin complex
GO:0034679 alpha9-beta1 integrin complex
GO:0035748 myelin sheath abaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045202 synapse
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025809
View Gene Order
ENSBTAG00000015910
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_160131
Fibronectin matrix formation pathway
REACT_20617
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22292
CHL1 interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_19271
Semaphorin interactions pathway
REACT_20676
Cell junction organization pathway
REACT_163942
Syndecan interactions pathway
REACT_18266
Axon guidance pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05140
Leishmaniasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
integrin1_pathway
Beta1 integrin cell surface interactions
reelinpathway
Reelin signaling pathway
integrin_cs_pathway
Integrin family cell surface interactions
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
myc_represspathway
Validated targets of C-MYC transcriptional repression
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
tcptp_pathway
Signaling events mediated by TCPTP
prlsignalingeventspathway
Signaling events mediated by PRL
syndecan_4_pathway
Syndecan-4-mediated signaling events
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
rhoa_pathway
RhoA signaling pathway
a4b7_pathway
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643813
RefSeq NM_002211 NM_033668 NM_133376 XM_005252448
HUGO
OMIM
CCDS CCDS7174
HPRD 00628
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca