InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHB3

Summary

InnateDB Gene

IDBG-68339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB3

Gene Name

EPH receptor B3

Synonyms

ETK2; HEK2; TYRO6

Species

Homo sapiens

Ensembl Gene

ENSG00000182580

Encoded Proteins

IDBP-68341

EPH receptor B3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:184561784-184582409

Strand

Forward strand

Band

q27.1

Transcripts

ENST00000330394	ENSP00000332118
ENST00000482987
ENST00000473079

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001655	urogenital system development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022038	corpus callosum development
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043088	regulation of Cdc42 GTPase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048538	thymus development
GO:0048546	digestive tract morphogenesis
GO:0050770	regulation of axonogenesis
GO:0051965	positive regulation of synapse assembly
GO:0060021	palate development
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis