Homo sapiens Gene: LILRB5 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-68391.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | LILRB5 | ||||||||||||||||||
Gene Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 | ||||||||||||||||||
Synonyms | CD85C; LIR-8; LIR8 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000105609 | ||||||||||||||||||
Encoded Proteins |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 19:54249431-54257301 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q13.42 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
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KEGG |
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O75023 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 10990 | ||||||||||||||||||
UniGene | Hs.655338 | ||||||||||||||||||
RefSeq | NM_001081442 NM_001081443 NM_006840 | ||||||||||||||||||
HUGO | HGNC:6609 | ||||||||||||||||||
OMIM | 604814 | ||||||||||||||||||
CCDS | CCDS12885 CCDS42611 CCDS46176 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC010492 AF025534 AK057072 AK223296 BC025704 | ||||||||||||||||||
GenPept | AAB87668 AAH25704 BAB71361 | ||||||||||||||||||
RNA Seq Atlas | 10990 | ||||||||||||||||||