Homo sapiens Gene: LIPH

Summary
InnateDB Gene IDBG-68529.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol LIPH
Gene Name lipase, member H
Synonyms AH; ARWH2; LAH2; LPDLR; mPA-PLA1; PLA1B
Species Homo sapiens
Ensembl Gene ENSG00000163898
Encoded Proteins
IDBP-68531 lipase, member H
IDBP-386265 lipase, member H
IDBP-386266 lipase, member H
IDBP-386267 lipase, member H
IDBP-386270 lipase, member H
Entrez Gene
Summary This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3: 185224050-185270401
Strand Reverse strand
Band q27.2
Transcripts
ENST00000296252  ENSP00000296252
ENST00000424591  ENSP00000396384
ENST00000435679  ENSP00000390228
ENST00000452897  ENSP00000408218
ENST00000429510  ENSP00000414311
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  1
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004620 phospholipase activity
GO:0008201 heparin binding
GO:0016787 hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000044626 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000001535 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WWY8 
TrEMBL A2IBA6 A2IBA8 F8WE09
UniProt Splice Variant
Entrez Gene 200879 
UniGene Hs.351126 Hs.68864
RefSeq NM_139248 
HUGO 18483 
OMIM 607365
CCDS CCDS3272 
HPRD 07392
IMGT
EMBL AC099661 AK074229 AK122651 AY036912 AY093498 BC064941 CH471052 EF186228 EF186229 EF186230
GenPept AAH64941  AAK63178  AAM18803  ABM67094  ABM67095  ABM67096  BAB85023  BAG53642  EAW78218 
ImmGen LIPH (murine) 
RNA Seq Atlas 200879