Version 5.4
Homo sapiens Gene: PIGU
Summary
InnateDB Gene IDBG-68583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGU
Gene Name phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101464
Encoded Proteins
IDBP-68585
phosphatidylinositol glycan anchor biosynthesis, class U
IDBP-68587
phosphatidylinositol glycan anchor biosynthesis, class U
IDBP-372320
phosphatidylinositol glycan anchor biosynthesis, class U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34560542-34677090
Strand Reverse strand
Band q11.22
Transcripts
ENST00000217446 ENSP00000217446
ENST00000374820 ENSP00000363953
ENST00000438215 ENSP00000395755
ENST00000480175
ENST00000462389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0034235 GPI anchor binding
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016255 attachment of GPI anchor to protein
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0046425 regulation of JAK-STAT cascade
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038383
View Gene Order
ENSBTAG00000011620
Not yet available
Pathways
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5JWU1
UniProt Splice Variant
Entrez Gene 128869
UniGene
RefSeq NM_080476
HUGO HGNC:15791
OMIM 608528
CCDS CCDS13239
HPRD 12250
IMGT
EMBL AL118520
GenPept
RNA Seq Atlas 128869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca