Version 5.4
Homo sapiens Gene: LILRA1
Summary
InnateDB Gene IDBG-68836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRA1
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
Synonyms CD85I; LIR-6; LIR6
Species Homo sapiens
Ensembl Gene ENSG00000104974
Encoded Proteins
IDBP-68838
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
IDBP-385037
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
IDBP-811431
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54573879-54602090
Strand Forward strand
Band q13.42
Transcripts
ENST00000251372 ENSP00000251372
ENST00000453777 ENSP00000413715
ENST00000473156
ENST00000495417
ENST00000477255
ENST00000618665 ENSP00000479482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0006952 defense response
GO:0007166 cell surface receptor signaling pathway
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.710507
RefSeq NM_001278318 NM_006863
HUGO
OMIM
CCDS CCDS12901 CCDS62802
HPRD 07272
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca