Version 5.4
Homo sapiens Gene: LILRB1
Summary
InnateDB Gene IDBG-68880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRB1
Gene Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Synonyms CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7
Species Homo sapiens
Ensembl Gene ENSG00000104972
Encoded Proteins
IDBP-68882
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237725
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237727
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237729
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237731
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237733
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-237735
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-384823
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-385010
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-385020
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
IDBP-385023
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54573879-54700954
Strand Forward strand
Band q13.42
Transcripts
ENST00000324602 ENSP00000315997
ENST00000396332 ENSP00000379623
ENST00000396331 ENSP00000379622
ENST00000396327 ENSP00000379618
ENST00000396321 ENSP00000379614
ENST00000396317 ENSP00000379610
ENST00000396315 ENSP00000379608
ENST00000418536 ENSP00000391514
ENST00000448689 ENSP00000409968
ENST00000427581 ENSP00000395004
ENST00000421584 ENSP00000410165
ENST00000480257
ENST00000473412
ENST00000462628
ENST00000487425
ENST00000480375
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0030107 HLA-A specific inhibitory MHC class I receptor activity
GO:0030109 HLA-B specific inhibitory MHC class I receptor activity
GO:0032393 MHC class I receptor activity
GO:0042169 SH2 domain binding
GO:0042288 MHC class I protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002309 T cell proliferation involved in immune response
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0007165 signal transduction
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0014063 negative regulation of serotonin secretion
GO:0031623 receptor internalization
GO:0032609 interferon-gamma production
GO:0032689 negative regulation of interferon-gamma production
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0035548 negative regulation of interferon-beta secretion
GO:0042130 negative regulation of T cell proliferation
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045806 negative regulation of endocytosis
GO:0045919 positive regulation of cytolysis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0046636 negative regulation of alpha-beta T cell activation
GO:0050776 regulation of immune response
GO:0051607 defense response to virus
GO:0051926 negative regulation of calcium ion transport
GO:0071222 cellular response to lipopolysaccharide
GO:0072643 interferon-gamma secretion
GO:0097028 dendritic cell differentiation
GO:2000669 negative regulation of dendritic cell apoptotic process
GO:2001180 negative regulation of interleukin-10 secretion
GO:2001183 negative regulation of interleukin-12 secretion
GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001193 positive regulation of gamma-delta T cell activation involved in immune response
GO:2001199 negative regulation of dendritic cell differentiation
GO:2001202 negative regulation of transforming growth factor-beta secretion
GO:2001205 negative regulation of osteoclast development
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.667388
RefSeq NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399 NM_006669
HUGO
OMIM
CCDS CCDS42614 CCDS42615 CCDS42616 CCDS42617 CCDS62803
HPRD 07273
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca