Homo sapiens Gene: LILRB4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-68893.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | LILRB4 | ||||||||||||||||||
Gene Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 | ||||||||||||||||||
Synonyms | CD85K; ILT-3; ILT3; LIR-5; LIR5 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000186818 | ||||||||||||||||||
Encoded Proteins |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 19:54643889-54670359 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q13.42 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
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KEGG |
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.604386 Hs.67846 | ||||||||||||||||||
RefSeq | NM_001278426 NM_001278427 NM_001278428 NM_001278429 NM_001278430 XM_006726292 XM_006726293 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS12902 CCDS42618 | ||||||||||||||||||
HPRD | 11996 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||