InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AHSG

Summary

InnateDB Gene

IDBG-68916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHSG

Gene Name

alpha-2-HS-glycoprotein

Synonyms

A2HS; AHS; FETUA; HSGA

Species

Homo sapiens

Ensembl Gene

ENSG00000145192

Encoded Proteins

IDBP-68918

alpha-2-HS-glycoprotein

IDBP-386389

alpha-2-HS-glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22842477

AHSG is an endogenous ligand of TLR4 that promotes inflammatory signalling leading to lipid-induced insulin resistance. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22842477

[Mus musculus] Ahsg is an endogenous ligand of Tlr4 that promotes inflammatory signalling leading to lipid-induced insulin resistance.

Entrez Gene

Summary

Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:186612923-186621318

Strand

Forward strand

Band

q27.3

Transcripts

ENST00000273784	ENSP00000273784
ENST00000411641	ENSP00000393887
ENST00000478441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0019210	kinase inhibitor activity

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0006907	pinocytosis
GO:0006953	acute-phase response
GO:0010951	negative regulation of endopeptidase activity
GO:0030500	regulation of bone mineralization
GO:0030502	negative regulation of bone mineralization
GO:0042326	negative regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050727	regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022868

View Gene Order

ENSBTAG00000000522

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

P02765

TrEMBL

UniProt Splice Variant

Entrez Gene

197

UniGene

Hs.324746

RefSeq

NM_001622

HUGO

HGNC:349

OMIM

138680

CCDS

CCDS3278

HPRD

00727

IMGT

EMBL

AB038689 AC068631 AF119895 AK292751 AK312969 BC048198 BC052590 CH471052 D67012 D67013 M16961

GenPept

AAA51683 AAF69649 AAH48198 AAH52590 BAA22651 BAA22652 BAA92189 BAF85440 BAG35808 EAW78189

RNA Seq Atlas

197