InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BIRC3

Summary

InnateDB Gene

IDBG-69045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC3

Gene Name

baculoviral IAP repeat containing 3

Synonyms

AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49

Species

Homo sapiens

Ensembl Gene

ENSG00000023445

Encoded Proteins

IDBP-69047

baculoviral IAP repeat containing 3

IDBP-594470

baculoviral IAP repeat containing 3

IDBP-587107

baculoviral IAP repeat containing 3

IDBP-808972

baculoviral IAP repeat containing 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18697935

BIRC3 is required for proper RIPK1 polyubiquitination and NF-kappaB activation upon TNF (TNF-alpha) treatment and regulates TNF-mediated NF-kappaB activation by binding to TNFRSF1A (TNFR1).

PMID 19464198

BIRC3 and BIRC2 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.

InnateDB Annotation from Orthologs

Summary

PMID 21447281

[Mus musculus] Birc3 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

Entrez Gene

Summary

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102317450-102339403

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000263464	ENSP00000263464
ENST00000526421
ENST00000528940
ENST00000532808	ENSP00000432907
ENST00000527309	ENSP00000431718
ENST00000527336
ENST00000615299	ENSP00000481903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	118 [view]
Protein-DNA	18 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006915	apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0039535	regulation of RIG-I signaling pathway
GO:0042326	negative regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0050727	regulation of inflammatory response
GO:0051291	protein heterooligomerization
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:2000116	regulation of cysteine-type endopeptidase activity
GO:2000378	negative regulation of reactive oxygen species metabolic process