Version 5.4
Homo sapiens Gene: GSS
Summary
InnateDB Gene IDBG-69124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSS
Gene Name glutathione synthetase
Synonyms GSHS; HEL-S-64p; HEL-S-88n
Species Homo sapiens
Ensembl Gene ENSG00000100983
Encoded Proteins
IDBP-69126
glutathione synthetase
IDBP-372507
glutathione synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34928430-34955817
Strand Reverse strand
Band q11.22
Transcripts
ENST00000216951 ENSP00000216951
ENST00000451957 ENSP00000407517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0016594 glycine binding
GO:0042277 peptide binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0006979 response to oxidative stress
GO:0007399 nervous system development
GO:0007568 aging
GO:0009410 response to xenobiotic stimulus
GO:0031667 response to nutrient levels
GO:0034612 response to tumor necrosis factor
GO:0043200 response to amino acid
GO:0044281 small molecule metabolic process
GO:0046686 response to cadmium ion
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027610
View Gene Order
ENSBTAG00000003504
Not yet available
Pathways
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.82327
RefSeq NM_000178 XM_005260406
HUGO
OMIM
CCDS CCDS13245
HPRD 03000
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca