Homo sapiens Gene: BTN3A2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-69145.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | BTN3A2 | ||||||||||||||||||
Gene Name | butyrophilin, subfamily 3, member A2 | ||||||||||||||||||
Synonyms | BT3.2; BTF4; BTN3.2; CD277 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000186470 | ||||||||||||||||||
Encoded Proteins |
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
butyrophilin, subfamily 3, member A2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
BTN3A2 is part of the BT3 family of immunoreceptors belonging to the extended B7 family that are expressed on the surface of resting and activated monocytes and monocyte-derived dendritic cells (iDC). BT3 molecules are involved in the regulation of the balance between immune activation and suppression.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. The gene resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other six family members, including BTN, BTN2A1, BTN2A2, BTN2A3, BTN3A1, and BTN3A3, on chromosome 6. The full-length protein encoded by this gene is a type I membrane protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 6:26365159-26378320 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p22.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.718089 | ||||||||||||||||||
RefSeq | NM_001197246 NM_001197247 NM_001197248 NM_001197249 NM_007047 XM_006714979 XM_006714981 XM_006714982 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS4605 CCDS56399 CCDS56400 | ||||||||||||||||||
HPRD | 12547 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||