Version 5.4
Homo sapiens Gene: MYH7B
Summary
InnateDB Gene IDBG-69150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH7B
Gene Name myosin, heavy chain 7B, cardiac muscle, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000078814
Encoded Proteins
IDBP-69154
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-372568
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-372573
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-372574
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-372575
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-372578
myosin, heavy chain 7B, cardiac muscle, beta
IDBP-808379
myosin, heavy chain 7B, cardiac muscle, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34975403-35002437
Strand Forward strand
Band q11.22
Transcripts
ENST00000262873 ENSP00000262873
ENST00000435272 ENSP00000391939
ENST00000453028 ENSP00000409103
ENST00000446156 ENSP00000395858
ENST00000456649 ENSP00000396368
ENST00000433934 ENSP00000412594
ENST00000470929
ENST00000481922
ENST00000618182 ENSP00000483640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0008152 metabolic process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0016020 membrane
GO:0016459 myosin complex
GO:0032982 myosin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074652
View Gene Order
ENSBTAG00000003512
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.414122
RefSeq NM_020884 XM_006723840
HUGO
OMIM
CCDS CCDS42869
HPRD 11379
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca