Version 5.4
Homo sapiens Gene: MPG
Summary
InnateDB Gene IDBG-6916.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPG
Gene Name N-methylpurine-DNA glycosylase
Synonyms AAG; ADPG; anpg; APNG; CRA36.1; MDG; Mid1; PIG11; PIG16
Species Homo sapiens
Ensembl Gene ENSG00000103152
Encoded Proteins
IDBP-6918
N-methylpurine-DNA glycosylase
IDBP-6920
N-methylpurine-DNA glycosylase
IDBP-234520
N-methylpurine-DNA glycosylase
IDBP-361045
N-methylpurine-DNA glycosylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:77007-85853
Strand Forward strand
Band p13.3
Transcripts
ENST00000219431 ENSP00000219431
ENST00000356432 ENSP00000348809
ENST00000397817 ENSP00000380918
ENST00000436333 ENSP00000388097
ENST00000475280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated
Total 64 [view]
Protein-Protein 62 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
GO:0005515 protein binding
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0043916 DNA-7-methylguanine glycosylase activity
GO:0052821 DNA-7-methyladenine glycosylase activity
GO:0052822 DNA-3-methylguanine glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006307 DNA dealkylation involved in DNA repair
GO:0045007 depurination
Cellular Component
GO:0005654 nucleoplasm
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020287
View Gene Order
ENSBTAG00000026422
Not yet available
Pathways
NETPATH
REACTOME
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_2176
Recognition and association of DNA glycosylase with site containing an affected purine pathway
REACT_1729
Cleavage of the damaged purine pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_804
Base-Excision Repair, AP Site Formation pathway
REACT_626
Depurination pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL A2IDA3
UniProt Splice Variant
Entrez Gene 4350
UniGene
RefSeq NM_001015052 NM_001015054 NM_002434
HUGO HGNC:7211
OMIM 156565
CCDS CCDS32345 CCDS32346 CCDS42087
HPRD 06766
IMGT
EMBL Z69720
GenPept CAM26663
RNA Seq Atlas 4350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca