Version 5.4
Homo sapiens Gene: EIF3B
Summary
InnateDB Gene IDBG-6921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3B
Gene Name eukaryotic translation initiation factor 3, subunit B
Synonyms EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9; PRT1
Species Homo sapiens
Ensembl Gene ENSG00000106263
Encoded Proteins
IDBP-6923
eukaryotic translation initiation factor 3, subunit B
IDBP-236285
eukaryotic translation initiation factor 3, subunit B
IDBP-361620
eukaryotic translation initiation factor 3, subunit B
IDBP-361648
eukaryotic translation initiation factor 3, subunit B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:2354086-2380745
Strand Forward strand
Band p22.3
Transcripts
ENST00000360876 ENSP00000354125
ENST00000397011 ENSP00000380206
ENST00000431643 ENSP00000408062
ENST00000413917 ENSP00000407785
ENST00000463229
ENST00000463026
ENST00000468250
ENST00000466199
ENST00000475415
ENST00000468611
ENST00000465670
ENST00000494658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 88 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0032947 protein complex scaffold
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056076
View Gene Order
ENSBTAG00000007474
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.730066
RefSeq NM_001037283 NM_003751
HUGO
OMIM
CCDS CCDS5332
HPRD 06795
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca