Version 5.4
Homo sapiens Gene: BTN3A1
Summary
InnateDB Gene IDBG-69277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTN3A1
Gene Name butyrophilin, subfamily 3, member A1
Synonyms BT3.1; BTF5; BTN3.1; CD277
Species Homo sapiens
Ensembl Gene ENSG00000026950
Encoded Proteins
IDBP-69279
butyrophilin, subfamily 3, member A1
IDBP-365834
butyrophilin, subfamily 3, member A1
IDBP-365841
butyrophilin, subfamily 3, member A1
IDBP-365845
butyrophilin, subfamily 3, member A1
IDBP-365849
butyrophilin, subfamily 3, member A1
IDBP-477731
butyrophilin, subfamily 3, member A1
IDBP-478159
butyrophilin, subfamily 3, member A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20947169
BTN3A1 is part of the BT3 family of immunoreceptors belonging to the extended B7 family that are expressed on the surface of resting and activated monocytes and monocyte-derived dendritic cells (iDC). BT3 molecules are involved in the regulation of the balance between immune activation and suppression.
Entrez Gene
Summary The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26402237-26415216
Strand Forward strand
Band p22.2
Transcripts
ENST00000289361 ENSP00000289361
ENST00000082468
ENST00000414912 ENSP00000406667
ENST00000425234 ENSP00000396684
ENST00000427334 ENSP00000399393
ENST00000450085 ENSP00000394937
ENST00000476549 ENSP00000420010
ENST00000465690
ENST00000506698 ENSP00000427013
ENST00000513047
ENST00000502361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050663 cytokine secretion
GO:0050798 activated T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0072643 interferon-gamma secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.628564
RefSeq NM_001145008 NM_001145009 NM_007048 NM_194441 XM_005248833 XM_005248834
HUGO
OMIM
CCDS CCDS4608 CCDS4609 CCDS47388 CCDS47389
HPRD 10693
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca