Version 5.4
Homo sapiens Gene: EXOC7
Summary
InnateDB Gene IDBG-69418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC7
Gene Name exocyst complex component 7
Synonyms 2-5-3p; EX070; EXO70; Exo70p; EXOC1; YJL085W
Species Homo sapiens
Ensembl Gene ENSG00000182473
Encoded Proteins
IDBP-69420
exocyst complex component 7
IDBP-69422
exocyst complex component 7
IDBP-69426
exocyst complex component 7
IDBP-293479
exocyst complex component 7
IDBP-293481
exocyst complex component 7
IDBP-384733
exocyst complex component 7
IDBP-384742
exocyst complex component 7
IDBP-384748
exocyst complex component 7
IDBP-764782
IDBP-761704
IDBP-762211
IDBP-760586
IDBP-810918
exocyst complex component 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:76081017-76121576
Strand Reverse strand
Band q25.1
Transcripts
ENST00000357231 ENSP00000349767
ENST00000332065 ENSP00000333806
ENST00000335146 ENSP00000334100
ENST00000405575 ENSP00000384368
ENST00000405068
ENST00000406660 ENSP00000385066
ENST00000411744 ENSP00000404322
ENST00000420116 ENSP00000389950
ENST00000442951 ENSP00000389723
ENST00000465252
ENST00000467929 ENSP00000466682
ENST00000467586
ENST00000494787
ENST00000460476
ENST00000486053
ENST00000589507 ENSP00000468364
ENST00000591724
ENST00000589210 ENSP00000468404
ENST00000592559 ENSP00000467042
ENST00000607838 ENSP00000475431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032584 growth cone membrane
GO:0034451 centriolar satellite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020792
View Gene Order
ENSBTAG00000007910
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
cdc42_pathway
CDC42 signaling events
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL K7ENP8
UniProt Splice Variant
Entrez Gene 23265
UniGene Hs.734508
RefSeq NM_001013839 NM_001145297 NM_001145298 NM_001145299 NM_001282313 NM_001282314 NM_015219 XM_006721787
HUGO HGNC:23214
OMIM 608163
CCDS CCDS11741 CCDS32738 CCDS45781 CCDS45782 CCDS45784 CCDS74164
HPRD 16292
IMGT
EMBL AC018665
GenPept
RNA Seq Atlas 23265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca