Homo sapiens Gene: CREM | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-69430.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CREM | ||||||||||||||||||||||
Gene Name | cAMP responsive element modulator | ||||||||||||||||||||||
Synonyms | CREM-2; hCREM-2; ICER | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000095794 | ||||||||||||||||||||||
Encoded Proteins |
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
cAMP responsive element modulator
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:35126791-35212958 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p11.21 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
TSH pathway
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REACTOME | |||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.600170 Hs.627185 Hs.713133 | ||||||||||||||||||||||
RefSeq | NM_001267562 NM_001267563 NM_001267564 NM_001267567 NM_001267570 NM_001881 NM_181571 NM_182717 NM_182718 NM_182719 NM_182720 NM_182721 NM_182723 NM_182724 NM_182769 NM_182770 NM_182771 NM_182772 NM_183011 NM_183012 NM_183013 NM_183060 XM_006717378 XM_006717379 XM_006717381 XM_006717383 XM_006717385 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS31181 CCDS53517 CCDS53518 CCDS53519 CCDS53520 CCDS53521 CCDS58074 CCDS58075 CCDS58076 CCDS7180 CCDS7181 CCDS7182 CCDS7183 CCDS7184 CCDS7185 CCDS7186 CCDS7187 CCDS7188 | ||||||||||||||||||||||
HPRD | 00444 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||