InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KDM5C

Summary

InnateDB Gene

IDBG-69550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM5C

Gene Name

lysine (K)-specific demethylase 5C

Synonyms

DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ; MRXSJ; SMCX; XE169

Species

Homo sapiens

Ensembl Gene

ENSG00000126012

Encoded Proteins

IDBP-362

lysine (K)-specific demethylase 5C

IDBP-69552

lysine (K)-specific demethylase 5C

IDBP-69554

lysine (K)-specific demethylase 5C

IDBP-69556

lysine (K)-specific demethylase 5C

IDBP-293380

lysine (K)-specific demethylase 5C

IDBP-588096

lysine (K)-specific demethylase 5C

IDBP-372923

lysine (K)-specific demethylase 5C

IDBP-372924

lysine (K)-specific demethylase 5C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:53191321-53225422

Strand

Reverse strand

Band

p11.22

Transcripts

ENST00000349663	ENSP00000344004
ENST00000375401	ENSP00000364550
ENST00000375383	ENSP00000364532
ENST00000375379	ENSP00000364528
ENST00000404049	ENSP00000385394
ENST00000452825	ENSP00000445176
ENST00000429877	ENSP00000409757
ENST00000428012	ENSP00000407277
ENST00000477109
ENST00000497100
ENST00000465402
ENST00000481369
ENST00000497995
ENST00000495519
ENST00000467093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	28 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453	histone demethylase activity (H3-K4 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0034720	histone H3-K4 demethylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025332

View Gene Order

ENSBTAG00000014943

Not yet available

Pathways

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P41229

TrEMBL

UniProt Splice Variant

Entrez Gene

8242

UniGene

Hs.631768

RefSeq

NM_001282622 NM_001146702 NM_004187 XM_005262035

HUGO

HGNC:11114

OMIM

314690

CCDS

CCDS65269 CCDS14351 CCDS55417

HPRD

02442

IMGT

EMBL

AK304732 AL139396 BC054499 CH471154 L25270 Z29650

GenPept

AAA61302 AAH54499 BAG65494 CAA82758 CAI39836 CAI39837 CAI39838 EAW93145

RNA Seq Atlas

8242