InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AANAT

Summary

InnateDB Gene

IDBG-69711.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AANAT

Gene Name

aralkylamine N-acetyltransferase

Synonyms

DSPS; SNAT

Species

Homo sapiens

Ensembl Gene

ENSG00000129673

Encoded Proteins

IDBP-69713

aralkylamine N-acetyltransferase

IDBP-245551

aralkylamine N-acetyltransferase

IDBP-764498

IDBP-757793

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:76453351-76470117

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000250615	ENSP00000250615
ENST00000392492	ENSP00000376282
ENST00000585649	ENSP00000468717
ENST00000587798	ENSP00000468239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004059	aralkylamine N-acetyltransferase activity
GO:0004060	arylamine N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006474	N-terminal protein amino acid acetylation
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0010043	response to zinc ion
GO:0014070	response to organic cyclic compound
GO:0030187	melatonin biosynthetic process
GO:0032868	response to insulin
GO:0034097	response to cytokine
GO:0034641	cellular nitrogen compound metabolic process
GO:0034695	response to prostaglandin E
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:0046688	response to copper ion
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0071320	cellular response to cAMP

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020804

View Gene Order

ENSBTAG00000014682

Not yet available

Pathways

NETPATH

REACTOME

REACT_15439

Serotonin and melatonin biosynthesis pathway

REACT_15513

Amine-derived hormones pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

Q16613

TrEMBL

F1T0I5 Q9GZS4 Q9H3T0

UniProt Splice Variant

Entrez Gene

UniGene

Hs.431417

RefSeq

NM_001166579 NM_001088

HUGO

HGNC:19

OMIM

600950

CCDS

CCDS54169 CCDS11745

HPRD

02974

IMGT

EMBL

AB023794 AB023796 AB023797 AB593119 AC015802 AF360979 BC069434 BC092430 BC126332 BC126334 CH471099 U40347 U40391

GenPept

AAC50554 AAC50555 AAH69434 AAH92430 AAI26333 AAI26335 AAK49981 BAB20313 BAB20315 BAB20316 BAJ84059 EAW89400

RNA Seq Atlas