Version 5.4
Homo sapiens Gene: LFNG
Summary
InnateDB Gene IDBG-6980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LFNG
Gene Name LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms SCDO3
Species Homo sapiens
Ensembl Gene ENSG00000106003
Encoded Proteins
IDBP-6982
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
IDBP-6984
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
IDBP-6986
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
IDBP-292523
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
IDBP-292525
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
IDBP-813275
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:2512529-2529177
Strand Forward strand
Band p22.3
Transcripts
ENST00000338732 ENSP00000343095
ENST00000359574 ENSP00000352579
ENST00000222725 ENSP00000222725
ENST00000402506 ENSP00000385764
ENST00000402045 ENSP00000384786
ENST00000493850
ENST00000614382 ENSP00000483986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001541 ovarian follicle development
GO:0001756 somitogenesis
GO:0007143 female meiotic division
GO:0007219 Notch signaling pathway
GO:0007386 compartment pattern specification
GO:0007389 pattern specification process
GO:0008152 metabolic process
GO:0008593 regulation of Notch signaling pathway
GO:0009887 organ morphogenesis
GO:0014807 regulation of somitogenesis
GO:0032092 positive regulation of protein binding
GO:0045747 positive regulation of Notch signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029570
View Gene Order
ENSBTAG00000040361
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_111102
Signal Transduction pathway
REACT_299
Signaling by NOTCH pathway
KEGG
hsa04330
Notch signaling pathway pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8NES3
TrEMBL
UniProt Splice Variant
Entrez Gene 3955
UniGene Hs.159142
RefSeq NM_001040167 NM_001040168 NM_001166355 NM_002304
HUGO HGNC:6560
OMIM 602576
CCDS CCDS34586 CCDS34587 CCDS55081 CCDS55082
HPRD
IMGT
EMBL AC092488 AF193612 AK096284 AY124582 BC014851 U94354
GenPept AAC51360 AAF07187 AAH14851 AAM93542 BAG53248
RNA Seq Atlas 3955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca