Version 5.4
Homo sapiens Gene: CFC1B
Summary
InnateDB Gene IDBG-69888.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFC1B
Gene Name cripto, FRL-1, cryptic family 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152093
Encoded Proteins
IDBP-69890
cripto, FRL-1, cryptic family 1B
IDBP-813825
cripto, FRL-1, cryptic family 1B
IDBP-813826
cripto, FRL-1, cryptic family 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130521197-130528604
Strand Forward strand
Band q21.1
Transcripts
ENST00000281882 ENSP00000281882
ENST00000619050 ENSP00000483368
ENST00000620207 ENSP00000480160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007369 gastrulation
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503733 Hs.567542
RefSeq NM_001079530 XM_005263737 XM_005263738
HUGO
OMIM
CCDS CCDS33286
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca