Version 5.4
Homo sapiens Gene: CDKN3
Summary
InnateDB Gene IDBG-6996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKN3
Gene Name cyclin-dependent kinase inhibitor 3
Synonyms CDI1; CIP2; KAP; KAP1
Species Homo sapiens
Ensembl Gene ENSG00000100526
Encoded Proteins
IDBP-6998
cyclin-dependent kinase inhibitor 3
IDBP-239243
cyclin-dependent kinase inhibitor 3
IDBP-369294
cyclin-dependent kinase inhibitor 3
IDBP-369298
cyclin-dependent kinase inhibitor 3
IDBP-598015
cyclin-dependent kinase inhibitor 3
IDBP-601367
cyclin-dependent kinase inhibitor 3
IDBP-589148
cyclin-dependent kinase inhibitor 3
IDBP-809166
cyclin-dependent kinase inhibitor 3
IDBP-809169
cyclin-dependent kinase inhibitor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:54396849-54420218
Strand Forward strand
Band q22.2
Transcripts
ENST00000335183 ENSP00000335357
ENST00000216414
ENST00000395577 ENSP00000378944
ENST00000442975 ENSP00000415333
ENST00000458126 ENSP00000396451
ENST00000555837
ENST00000543789 ENSP00000440404
ENST00000556102 ENSP00000450711
ENST00000541304 ENSP00000445572
ENST00000556305
ENST00000620759 ENSP00000479875
ENST00000611205 ENSP00000480289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037628
View Gene Order
ENSBTAG00000019496
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1033
UniGene
RefSeq NM_001130851 NM_005192 XM_005267258
HUGO HGNC:1791
OMIM 123832
CCDS CCDS45109 CCDS9716
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 1033

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca