Version 5.4
Homo sapiens Gene: MSRA
Summary
InnateDB Gene IDBG-7004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSRA
Gene Name methionine sulfoxide reductase A
Synonyms PMSR
Species Homo sapiens
Ensembl Gene ENSG00000175806
Encoded Proteins
IDBP-7006
methionine sulfoxide reductase A
IDBP-7008
methionine sulfoxide reductase A
IDBP-360870
methionine sulfoxide reductase A
IDBP-482229
methionine sulfoxide reductase A
IDBP-599299
methionine sulfoxide reductase A
IDBP-478262
methionine sulfoxide reductase A
IDBP-483770
methionine sulfoxide reductase A
IDBP-591362
methionine sulfoxide reductase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:10054268-10428891
Strand Forward strand
Band p23.1
Transcripts
ENST00000382490 ENSP00000371930
ENST00000317173 ENSP00000313921
ENST00000441698 ENSP00000410912
ENST00000518255 ENSP00000429461
ENST00000521209 ENSP00000435644
ENST00000522907 ENSP00000428214
ENST00000523637
ENST00000521686 ENSP00000427725
ENST00000517594
ENST00000528246 ENSP00000436839
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006555 methionine metabolic process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054733
View Gene Order
ENSBTAG00000021632
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135670 NM_001135671 NM_001199729 NM_012331
HUGO
OMIM
CCDS CCDS47798 CCDS47799 CCDS56522 CCDS5975
HPRD 03152
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca