InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRSF2

Summary

InnateDB Gene

IDBG-70058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF2

Gene Name

serine/arginine-rich splicing factor 2

Synonyms

PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b

Species

Homo sapiens

Ensembl Gene

ENSG00000161547

Encoded Proteins

IDBP-70060

serine/arginine-rich splicing factor 2

IDBP-70064

serine/arginine-rich splicing factor 2

IDBP-245561

serine/arginine-rich splicing factor 2

IDBP-384861

serine/arginine-rich splicing factor 2

IDBP-594941

serine/arginine-rich splicing factor 2

IDBP-763480

IDBP-761788

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:76734115-76737374

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000359995	ENSP00000353089
ENST00000358156	ENSP00000350877
ENST00000392485	ENSP00000376276
ENST00000452355	ENSP00000391278
ENST00000508921	ENSP00000441780
ENST00000582449
ENST00000585202	ENSP00000462425
ENST00000589919
ENST00000583836	ENSP00000463317
ENST00000592676
ENST00000586778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	97 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:2001141	regulation of RNA biosynthetic process