Version 5.4
Homo sapiens Gene: HIST1H2BK
Summary
InnateDB Gene IDBG-70101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2BK
Gene Name histone cluster 1, H2bk
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197903
Encoded Proteins
IDBP-70105
histone cluster 1, H2bk
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:27146418-27146798
Strand Reverse strand
Band p22.1
Transcripts
ENST00000356950 ENSP00000349430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0019731 antibacterial humoral response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_75925
Amyloids pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_2232
RNA Polymerase I Promoter Opening pathway
REACT_27271
Meiotic recombination pathway
REACT_172610
HATs acetylate histones pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_267652
DNA methylation pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172623
Chromatin organization pathway
REACT_765
Mitotic Prophase pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_111183
Meiosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt O60814
TrEMBL A0A024RCL8
UniProt Splice Variant
Entrez Gene 85236
UniGene
RefSeq NM_080593
HUGO HGNC:13954
OMIM 615045
CCDS CCDS4621
HPRD
IMGT
EMBL AF531294 AJ223352 AK292062 AL021807 BC000893 BC051872 BC064959 BC108737 CH471081
GenPept AAH00893 AAH51872 AAH64959 AAI08738 AAN06694 BAF84751 CAA11276 CAA16945 EAX03084 EAX03085
RNA Seq Atlas 85236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca