Version 5.4
Homo sapiens Gene: RPL17
Summary
InnateDB Gene IDBG-702139.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL17
Gene Name ribosomal protein L17
Synonyms L17; PD-1; RPL23
Species Homo sapiens
Ensembl Gene ENSG00000265681
Encoded Proteins
IDBP-726118
IDBP-725723
IDBP-725809
IDBP-726418
IDBP-727040
IDBP-727593
IDBP-726453
IDBP-727258
IDBP-726400
IDBP-726875
IDBP-810302
ribosomal protein L17
IDBP-810310
ribosomal protein L17
IDBP-810312
ribosomal protein L17
IDBP-810313
ribosomal protein L17
IDBP-810315
ribosomal protein L17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:49488453-49492565
Strand Reverse strand
Band q21.1
Transcripts
ENST00000581305
ENST00000584364
ENST00000578532 ENSP00000463885
ENST00000582588
ENST00000583637 ENSP00000462203
ENST00000581091
ENST00000583036 ENSP00000464586
ENST00000581741
ENST00000578966
ENST00000579408 ENSP00000463842
ENST00000582935
ENST00000579495
ENST00000582782
ENST00000580261 ENSP00000462385
ENST00000578528 ENSP00000462508
ENST00000581373 ENSP00000462944
ENST00000580387 ENSP00000461910
ENST00000579248 ENSP00000462023
ENST00000580210 ENSP00000463490
ENST00000618619 ENSP00000482577
ENST00000617346 ENSP00000481145
ENST00000615760 ENSP00000480215
ENST00000615479 ENSP00000481587
ENST00000618613 ENSP00000480555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
Experimentally validated
Total 105 [view]
Protein-Protein 105 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000062328
View Gene Order
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_9491
Viral mRNA Translation pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_6167
Influenza Infection pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000985 NM_001035006 NM_001199340 NM_001199341 NM_001199342 NM_001199343 NM_001199344 NM_001199345
HUGO
OMIM
CCDS CCDS45865 CCDS56070
HPRD 04715
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca