Version 5.4
Mus musculus Gene: Hist1h2bl
Summary
InnateDB Gene IDBG-704109.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist1h2bl
Gene Name histone cluster 1, H2bl
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000094338
Encoded Proteins
IDBP-134089
histone cluster 1, H2bl
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185130:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:21715763-21716143
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000091756 ENSMUSP00000089350
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000185130
View Gene Order
Pathways
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
REACT_268475
DNA methylation pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_198624
Meiosis pathway
KEGG
mmu05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_75925
Amyloids pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_2232
RNA Polymerase I Promoter Opening pathway
REACT_27271
Meiotic recombination pathway
REACT_172610
HATs acetylate histones pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_267652
DNA methylation pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172623
Chromatin organization pathway
REACT_765
Mitotic Prophase pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_111183
Meiosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt P10853
TrEMBL A0JLV3
UniProt Splice Variant
Entrez Gene 319187
UniGene Mm.377880
RefSeq NM_178199
OMIM
CCDS CCDS26287
HPRD
IMGT
MGI ID MGI:2448403
MGI Symbol Hist1h2bl
EMBL AL589651 AL589879 AL590614 AY158927 AY158929 AY158932 AY158935 BC115792 U62669 X05862
GenPept AAB04762 AAI15793 AAO06237 AAO06239 AAO06242 AAO06245 CAA29290 CAI24103 CAI24111 CAI25462 CAI25467 CAI26130
RNA Seq Atlas 319180 319183 319185 319187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca