InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SULT1A3

Summary

InnateDB Gene

IDBG-705794.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A3

Gene Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

Synonyms

HAST; HAST3; M-PST; ST1A3; ST1A3/ST1A4; ST1A5; STM; TL-PST

Species

Homo sapiens

Ensembl Gene

ENSG00000261052

Encoded Proteins

IDBP-25887

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

IDBP-25891

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

IDBP-240151

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

IDBP-750453

IDBP-747574

IDBP-750703

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:30199228-30204310

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000355544	ENSP00000347739
ENST00000338971	ENSP00000343645
ENST00000395138	ENSP00000378570
ENST00000563638	ENSP00000456391
ENST00000561533
ENST00000562257
ENST00000563322	ENSP00000454518
ENST00000567309
ENST00000569409
ENST00000561549
ENST00000569485	ENSP00000455372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008202	steroid metabolic process
GO:0009812	flavonoid metabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation