InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SOCS3

Summary

InnateDB Gene

IDBG-70676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS3

Gene Name

suppressor of cytokine signaling 3

Synonyms

ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

Species

Homo sapiens

Ensembl Gene

ENSG00000184557

Encoded Proteins

IDBP-70678

suppressor of cytokine signaling 3

IDBP-758675

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10882725

SOCS3 inhibits the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis (EPO) by binding the JAK2 and EPO receptor, respectively.

PMID 10373548

SOCS3 is rapidly induced by IL-2 in T cells where it acts to inhibit IL-2 responses in a classical negative feedback loop by suppressing STAT5 phosphorylation and lymphocyte proliferation.

PMID 18989459

SOCS3 protein is a potent endogenous inhibitor of Janus kinase (JAK)/STAT signalling and influenza A virus inhibits type I IFN signalling via NF-kappaB-dependent induction of SOCS3 expression.

PMID 20631305

SOCS3 is a molecular inhibitor of IFN signalling and SOCS3 expression, induced by stimuli present in the Human immunodeficiency virus (HIV)-1-infected brain, such as transactivator of transcription, inhibits antiviral IFN-beta signalling to enhance HIV-1 replication in macrophages, allowing HIV-1 to evade the protective innate immune response within the central nervous system.

Entrez Gene

Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:78356778-78360077

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000330871	ENSP00000330341
ENST00000587578	ENSP00000464727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	110 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060674	placenta blood vessel development
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation