Homo sapiens Gene: MUC4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-70699.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MUC4 | ||||||||||||||||||
Gene Name | mucin 4, cell surface associated | ||||||||||||||||||
Synonyms | ASGP; HSA276359; MUC-4 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000145113 | ||||||||||||||||||
Encoded Proteins |
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
mucin 4, cell surface associated
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008] The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 3:195746765-195812277 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q29 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Termination of O-glycan biosynthesis pathway
O-linked glycosylation of mucins pathway
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E7EUL9 O75456 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 4585 | ||||||||||||||||||
UniGene | Hs.369646 Hs.711257 | ||||||||||||||||||
RefSeq | NM_004532 NM_018406 NM_138297 | ||||||||||||||||||
HUGO | HGNC:7514 | ||||||||||||||||||
OMIM | 158372 | ||||||||||||||||||
CCDS | CCDS3310 CCDS3311 CCDS54700 | ||||||||||||||||||
HPRD | 11829 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC069513 AC233280 AF058804 | ||||||||||||||||||
GenPept | AAC34751 | ||||||||||||||||||
RNA Seq Atlas | 4585 | ||||||||||||||||||