InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCM6

Summary

InnateDB Gene

IDBG-70952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM6

Gene Name

minichromosome maintenance complex component 6

Synonyms

MCG40308; Mis5; P105MCM

Species

Homo sapiens

Ensembl Gene

ENSG00000076003

Encoded Proteins

IDBP-70954

minichromosome maintenance complex component 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:135839626-135876426

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000264156	ENSP00000264156
ENST00000492091
ENST00000483902

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	108 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0042802	identical protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process