Version 5.4
Homo sapiens Gene: LGALS3BP
Summary
InnateDB Gene IDBG-71005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS3BP
Gene Name lectin, galactoside-binding, soluble, 3 binding protein
Synonyms 90K; BTBD17B; CyCAP; gp90; M2BP; MAC-2-BP; TANGO10B
Species Homo sapiens
Ensembl Gene ENSG00000108679
Encoded Proteins
IDBP-71007
lectin, galactoside-binding, soluble, 3 binding protein
IDBP-763393
IDBP-759989
IDBP-762812
IDBP-763703
IDBP-763854
IDBP-761353
IDBP-763711
IDBP-763774
IDBP-762124
IDBP-763279
IDBP-759226
IDBP-759832
IDBP-761404
IDBP-762938
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78971238-78980109
Strand Reverse strand
Band q25.3
Transcripts
ENST00000262776 ENSP00000262776
ENST00000589775 ENSP00000468774
ENST00000586720 ENSP00000465982
ENST00000585407 ENSP00000465729
ENST00000587311 ENSP00000467976
ENST00000588508
ENST00000588198 ENSP00000468480
ENST00000589906 ENSP00000465380
ENST00000589527 ENSP00000467211
ENST00000592255
ENST00000588990 ENSP00000468131
ENST00000586300
ENST00000588899 ENSP00000466318
ENST00000591274 ENSP00000468586
ENST00000591778 ENSP00000465120
ENST00000587251 ENSP00000466850
ENST00000587310 ENSP00000466333
ENST00000588205 ENSP00000467646
ENST00000588587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033880
View Gene Order
ENSBTAG00000001368
Not yet available
Cross-References
SwissProt
TrEMBL K7EJY8
UniProt Splice Variant
Entrez Gene 3959
UniGene Hs.514535
RefSeq NM_005567
HUGO HGNC:6564
OMIM 600626
CCDS CCDS11759
HPRD 02796
IMGT
EMBL AC100788
GenPept
RNA Seq Atlas 3959

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca