InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ANXA1

Summary

InnateDB Gene

IDBG-71054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA1

Gene Name

annexin A1

Synonyms

ANX1; LPC1

Species

Homo sapiens

Ensembl Gene

ENSG00000135046

Encoded Proteins

IDBP-71056

annexin A1

IDBP-71060

annexin A1

IDBP-372950

annexin A1

IDBP-372953

annexin A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20679535

ANXA1 is cleaved by CAPN1 to generate a N-terminally truncated form of ANXA1 shown to be anti-inflammatory and able to activate ERK. This C-terminal ANXA1 peptide functions by increasing ICAM1 clustering around adherent neutrophils to anchor them to the endothelium and promote transmigration through the transcellular route.

InnateDB Annotation from Orthologs

Summary

PMID 25533809

[Mus musculus] Anxa1-/- mice are more susceptible to Mycobacterium tuberculosis infection as evidenced by a transient increase in pulmonary bacterial burden, exacerbated and disorganized granulomatous inflammation and impaired ability of Anxa1-/- dendritic cells to activate naïve T cells.

Entrez Gene

Summary

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:73151757-73170393

Strand

Forward strand

Band

q21.13

Transcripts

ENST00000257497	ENSP00000257497
ENST00000376911	ENSP00000366109
ENST00000456643	ENSP00000412489
ENST00000415424	ENSP00000414013
ENST00000468639
ENST00000495713
ENST00000489109
ENST00000491192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	87 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0003727	single-stranded RNA binding
GO:0004386	helicase activity
GO:0004859	phospholipase inhibitor activity
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0030674	protein binding, bridging
GO:0033676	double-stranded DNA-dependent ATPase activity
GO:0036310	annealing helicase activity
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000733	DNA strand renaturation
GO:0001780	neutrophil homeostasis
GO:0006200	ATP catabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0009725	response to hormone
GO:0010165	response to X-ray
GO:0014070	response to organic cyclic compound
GO:0018149	peptide cross-linking
GO:0030073	insulin secretion
GO:0030216	keratinocyte differentiation
GO:0030850	prostate gland development
GO:0031018	endocrine pancreas development
GO:0031340	positive regulation of vesicle fusion
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0031960	response to corticosteroid
GO:0032355	response to estradiol
GO:0032508	DNA duplex unwinding
GO:0033031	positive regulation of neutrophil apoptotic process
GO:0036292	DNA rewinding
GO:0042063	gliogenesis
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0046632	alpha-beta T cell differentiation
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0051384	response to glucocorticoid
GO:0060206	estrous cycle phase
GO:0070301	cellular response to hydrogen peroxide
GO:0070365	hepatocyte differentiation
GO:0070459	prolactin secretion
GO:0070555	response to interleukin-1
GO:0071385	cellular response to glucocorticoid stimulus
GO:0097350	neutrophil clearance
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:1900138	negative regulation of phospholipase A2 activity
GO:2000483	negative regulation of interleukin-8 secretion

Cellular Component

GO:0001533	cornified envelope
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0031966	mitochondrial membrane
GO:0042383	sarcolemma
GO:0042629	mast cell granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome