Version 5.4
Homo sapiens Gene: HNMT
Summary
InnateDB Gene IDBG-71109.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNMT
Gene Name histamine N-methyltransferase
Synonyms HMT; HNMT-S1; HNMT-S2
Species Homo sapiens
Ensembl Gene ENSG00000150540
Encoded Proteins
IDBP-71111
histamine N-methyltransferase
IDBP-71113
histamine N-methyltransferase
IDBP-71115
histamine N-methyltransferase
IDBP-294147
histamine N-methyltransferase
IDBP-484269
histamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:137964020-138016364
Strand Forward strand
Band q22.1
Transcripts
ENST00000280097 ENSP00000280097
ENST00000329366 ENSP00000333259
ENST00000280096 ENSP00000280096
ENST00000410115 ENSP00000386940
ENST00000475675 ENSP00000419415
ENST00000467390
ENST00000485653
ENST00000480534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0002347 response to tumor cell
GO:0006972 hyperosmotic response
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange
GO:0014075 response to amine
GO:0032259 methylation
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026986
View Gene Order
ENSBTAG00000014432
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00340
Histidine metabolism pathway
INOH
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.42151 Hs.593840 Hs.738792
RefSeq NM_001024074 NM_001024075 NM_006895
HUGO
OMIM
CCDS CCDS2181 CCDS33296 CCDS33297
HPRD 05575
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca