Version 5.4
Homo sapiens Gene: CBX4
Summary
InnateDB Gene IDBG-71254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBX4
Gene Name chromobox homolog 4
Synonyms NBP16; PC2
Species Homo sapiens
Ensembl Gene ENSG00000141582
Encoded Proteins
IDBP-71258
chromobox homolog 4
IDBP-385134
chromobox homolog 4
IDBP-758087
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:79833156-79839429
Strand Reverse strand
Band q25.3
Transcripts
ENST00000269397 ENSP00000269397
ENST00000448310 ENSP00000415348
ENST00000495122 ENSP00000461198
ENST00000494546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 110 [view]
Protein-Protein 107 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0019899 enzyme binding
GO:0032183 SUMO binding
GO:0035064 methylated histone binding
GO:0044212 transcription regulatory region DNA binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0016925 protein sumoylation
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039989
View Gene Order
ENSBTAG00000009782
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743401
RefSeq NM_003655
HUGO
OMIM
CCDS CCDS32758
HPRD 04357
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca