InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAK2

Summary

InnateDB Gene

IDBG-71333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAK2

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 2

Synonyms

PAK65; PAKgamma

Species

Homo sapiens

Ensembl Gene

ENSG00000180370

Encoded Proteins

IDBP-71335

p21 protein (Cdc42/Rac)-activated kinase 2

IDBP-387122

p21 protein (Cdc42/Rac)-activated kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:196739857-196832647

Strand

Forward strand

Band

q29

Transcripts

ENST00000327134	ENSP00000314067
ENST00000426668	ENSP00000402927
ENST00000481344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	92 [view]
Protein-Protein	91 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0030296	protein tyrosine kinase activator activity
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0016032	viral process
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0040008	regulation of growth
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0046777	protein autophosphorylation
GO:0050690	regulation of defense response to virus by virus
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis