Homo sapiens Gene: SENP5
Summary
InnateDB Gene IDBG-71372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP5
Gene Name SUMO1/sentrin specific peptidase 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119231
Encoded Proteins
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific peptidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196867856-196934714
Strand Forward strand
Band q29
Transcripts
ENST00000323460 ENSP00000327197
ENST00000445299 ENSP00000390231
ENST00000419026 ENSP00000396927
ENST00000448068 ENSP00000405663
ENST00000434433 ENSP00000415227
ENST00000489744
ENST00000463245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
GO:0016925 protein sumoylation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Processing and activation of SUMO pathway
Metabolism of proteins pathway
SUMO is proteolytically processed pathway
SUMOylation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.240770 Hs.601136
RefSeq NM_152699
HUGO
OMIM
CCDS CCDS3322
HPRD 10222
IMGT
EMBL
GenPept
RNA Seq Atlas