Version 5.4
Homo sapiens Gene: MFI2
Summary
InnateDB Gene IDBG-71450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFI2
Gene Name antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Synonyms CD228; MAP97; MTF1
Species Homo sapiens
Ensembl Gene ENSG00000163975
Encoded Proteins
IDBP-71452
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
IDBP-71454
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
IDBP-387158
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196988621-197029816
Strand Reverse strand
Band q29
Transcripts
ENST00000296350 ENSP00000296350
ENST00000296351 ENSP00000296351
ENST00000439320 ENSP00000393439
ENST00000469783
ENST00000489445
ENST00000491399
ENST00000473501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008199 ferric iron binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0010756 positive regulation of plasminogen activation
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0097286 iron ion import
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022780
View Gene Order
ENSBTAG00000002998
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.184727 Hs.694099
RefSeq NM_005929 NM_033316
HUGO
OMIM
CCDS CCDS3325 CCDS3326
HPRD 01122
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca