InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACVR2A

Summary

InnateDB Gene

IDBG-71761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR2A

Gene Name

activin A receptor, type IIA

Synonyms

ACTRII; ACVR2

Species

Homo sapiens

Ensembl Gene

ENSG00000121989

Encoded Proteins

IDBP-71763

activin A receptor, type IIA

IDBP-294096

activin A receptor, type IIA

IDBP-587254

activin A receptor, type IIA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq, Jul 2008]
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:147844517-147930826

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000241416	ENSP00000241416
ENST00000404590	ENSP00000384338
ENST00000487959
ENST00000462659
ENST00000465329
ENST00000495775
ENST00000535787	ENSP00000439988

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015026	coreceptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017002	activin-activated receptor activity
GO:0019838	growth factor binding
GO:0030165	PDZ domain binding
GO:0034711	inhibin binding
GO:0043621	protein self-association
GO:0046872	metal ion binding
GO:0048185	activin binding

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007283	spermatogenesis
GO:0007368	determination of left/right symmetry
GO:0007498	mesoderm development
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009966	regulation of signal transduction
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030510	regulation of BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0042713	sperm ejaculation
GO:0043084	penile erection
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0048706	embryonic skeletal system development
GO:0050999	regulation of nitric-oxide synthase activity
GO:0060011	Sertoli cell proliferation
GO:0071773	cellular response to BMP stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0034673	inhibin-betaglycan-ActRII complex