InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: VKORC1

Summary

InnateDB Gene

IDBG-717692.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VKORC1

Gene Name

Vitamin K epoxide reductase complex subunit 1

Synonyms

D7Wsu86e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000096145

Encoded Proteins

IDBP-210440

vitamin K epoxide reductase complex, subunit 1

IDBP-400183

vitamin K epoxide reductase complex, subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:127893067-127895617

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033074	ENSMUSP00000033074
ENSMUST00000119922	ENSMUSP00000112542

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038	quinone binding

Biological Process

GO:0007596	blood coagulation
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0042371	vitamin K biosynthetic process
GO:0042373	vitamin K metabolic process
GO:0050820	positive regulation of coagulation
GO:0055114	oxidation-reduction process
GO:0060348	bone development