Version 5.4
Homo sapiens Gene: USP28
Summary
InnateDB Gene IDBG-71844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP28
Gene Name ubiquitin specific peptidase 28
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000048028
Encoded Proteins
IDBP-71846
ubiquitin specific peptidase 28
IDBP-601752
ubiquitin specific peptidase 28
IDBP-602113
ubiquitin specific peptidase 28
IDBP-597110
ubiquitin specific peptidase 28
IDBP-596213
ubiquitin specific peptidase 28
IDBP-596388
ubiquitin specific peptidase 28
IDBP-602932
ubiquitin specific peptidase 28
IDBP-599126
ubiquitin specific peptidase 28
IDBP-583549
ubiquitin specific peptidase 28
IDBP-587046
ubiquitin specific peptidase 28
IDBP-597907
ubiquitin specific peptidase 28
IDBP-589634
ubiquitin specific peptidase 28
IDBP-590675
ubiquitin specific peptidase 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:113797874-113875570
Strand Reverse strand
Band q23.2
Transcripts
ENST00000003302 ENSP00000003302
ENST00000544967 ENSP00000442431
ENST00000545540 ENSP00000444991
ENST00000544272
ENST00000540438 ENSP00000441513
ENST00000538224 ENSP00000440260
ENST00000538475 ENSP00000442257
ENST00000537706 ENSP00000445743
ENST00000545608 ENSP00000438050
ENST00000535607 ENSP00000437688
ENST00000537490 ENSP00000445722
ENST00000537642 ENSP00000440799
ENST00000542033
ENST00000540925 ENSP00000446284
ENST00000544750 ENSP00000437450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0034644 cellular response to UV
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032267
View Gene Order
ENSBTAG00000002323
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503891
RefSeq NM_001301029 NM_020886 XM_005271637 XM_005271638 XM_005271639 XM_005271641
HUGO
OMIM
CCDS CCDS31680 CCDS73394
HPRD 15632
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca